Neonatal nasal intermittent positive pressure ventilation efficacy and lung pressure transmission
The objective of this study was to evaluate carbon dioxide (CO2) clearance, delivered pressures and tidal volume (Vt) during neonatal nasal intermittent positive pressure ventilation (NIPPV) with two commonly used interfaces.
Role for neonatal D-serine signaling: prevention of physiological and behavioral deficits in adult Pick1 knock-out mice
NMDA glutamate receptors have key roles in brain development, function and dysfunction. Regulatory roles of D-serine in NMDA receptor-mediated synaptic plasticity have been reported. Nonetheless, it is unclear whether and how neonatal deficits in NMDA-receptor-mediated neurotransmission affect adult brain functions and behavior.
Effects of antenatal magnesium sulphate treatment for neonatal neuro-protection on cerebral oxygen kinetics
The underlying neuro-protective mechanisms of antenatal magnesium sulphate (MgSO4) in infants born preterm remain poorly understood. Early neonatal brain injury may be preceded by low cerebral blood flow and elevated cerebral fractional oxygen extraction (cFTOE). This study investigated the effect of antenatal MgSO4 on cerebral oxygen delivery, consumption and cFTOE in preterm infants.
How to deal with mortality in Perinatal Research: Part 2
"The trials of therapeutic hypothermia were necessarily unblinded, but death in babies with severe HIE often follows a decision to redirect care."
How to deal with mortality in perinatal research: Part 1.
"Obstetric attitudes can affect survival, well before babies get to the NICU, if we make the denominator fetuses who were alive when the mother was admitted to obstetrics, then we get different figures, compared to fetuses born alive, or to babies admitted to NICU."
Antibiotics may be overused in many neonatal ICUs, study finds
Antibiotics appear to be overused in many neonatal intensive care units, new research suggests. Just how overused these medications were varied widely, the study authors found. Some neonatal intensive care units (NICUs) gave antibiotics to newborns at a rate 40 times greater than rates at other NICUs, even when there was little difference in infection rates.
Case Report Details Fatal Neonatal Encephalopathy and Lactic Acidosis Caused by COQ9 Deficiency
Coenzyme Q10 (CoQ10) is a lipid-soluble, naturally occuring enzyme that is a key part of the mitochondrial respiratory chain, shuttling electrons and creating a kind of cycle between the oxidized and the reduced form of mitochondria. CoQ10 also links mitochondrial fatty acid ?-oxidation into this respiratory chain and plays other key roles in keeping the "cellular powerhouses" of cells functional.
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Neonatal respiratory distress syndrome revealing a cervical bronchogenic cyst: a case reported
Bronchogenic cyst is a congenital malformation, rarely located in the cervical region and almost never involved in a neonate with acute respiratory distress syndrome caused by a large left cervical mass. Intubation was difficult due to tracheal deviation.